On May 4, 1988, a massive explosion occurred at the PEPCON chemical plant in Henderson, Nevada, where ammonium perchlorate used for space shuttle fuel was being stored. The disaster killed 2 people, injured 372 others, and caused over 100 million dollars in property damage.
The explosion was so powerful it shattered windows 10 miles away and registered seismic activity similar to a small earthquake. Fires and a series of secondary blasts ripped through the facility, sending huge smoke clouds into the air and forcing nearby residents to evacuate.
Fun fact: The blast was one of the most powerful non nuclear explosions ever recorded in the United States and was visible from over 20 miles away.