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Enos (born about 1957 – died November 4, 1962) was the second chimpanzee launched into space by NASA. He was the first and only chimpanzee, and third hominid after cosmonauts Yuri Gagarin and Gherman Titov, to orbit the Earth. Enos's flight occurred on November 29, 1961.Enos was brought from the Miami Rare Bird Farm on April 3, 1960. He completed more than 1,250 training hours at the University of Kentucky and Holloman Air Force Base. Training was more intense for him than for his predecessor Ham, who had become the first great ape in space in January 1961, because Enos was exposed to weightlessness and higher gs for longer periods of time. His training included psychomotor instruction and aircraft flights.Enos was selected for his Project Mercury flight only three days before launch. Two months prior, NASA launched Mercury-Atlas 4 on September 13, 1961, to conduct an identical mission with a "crewman simulator" on board. Enos flew into space aboard Mercury-Atlas 5 on November 29, 1961. He completed his first orbit in 1 hour and 28.5 minutes.Enos was scheduled to complete three orbits, but the mission was aborted after two, due to two issues: capsule overheating and a malfunctioning "avoidance conditioning" test subjecting the primate to 76 electrical shocks. According to one history of primatology, "The chimpanzee, about five years old, behaved like a true hero: despite the malfunctions of the electronic system, he conscientiously performed all the tasks he had learned during the entire flight of over three hours...Enos demonstrated that he was careful to successfully complete his mission and that he perfectly understood what was expected of him."The capsule was brought aboard USS Stormes in the late afternoon and Enos was immediately taken below deck by his Air Force handlers. Stormes arrived in Bermuda the next day.Enos's flight was a full dress rehearsal for the next Mercury launch on February 20, 1962, which would make John Glenn the first American to orbit Earth, after astronauts Alan Shepard, Jr. and Gus Grissom's successful suborbital space flights.
On November 4, 1962, Enos died of shigellosis-related dysentery, which was resistant to then-known antibiotics. He was constantly observed for two months before his death. Pathologists reported no symptoms that could be attributed or related to his previous space flight.

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